COVID-19: DRDO's anti-coronavirus drug 2-DG to be released today

The first batch of anti-COVID-19 drug 2-DG, developed by the Defence Research and Development Organisation (DRDO), will be released today Monday by Defence Minister Rajnath Singh and Health Minister Harsh Vardhan.

The 2-DG (2-deoxy-D-glucose), an anti-COVID-19 therapeutic application of the drug, has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a lab of Defence Research and Development Organisation (DRDO), in collaboration with Dr Reddys Laboratories (DRL). 

The Drugs Controller General of India (DGCI) has approved the oral drug for emergency use as an adjunct therapy in moderate to severe coronavirus patients, the defence ministry said earlier this month.

The officials said the first batch of the drug will be released by the two ministers at an event at the Defence Research and Development Organisation (DRDO) headquarters.

The ministry, on May 8, said the clinical trials of the drug, 2-deoxy-D-glucose (2-DG), showed that it helps in a faster recovery of hospitalised patients and reduces supplemental oxygen dependence.

The drug's approval has come when India is grappling with a record-breaking wave of the coronavirus pandemic that has stretched the country's healthcare infrastructure to its limit.

"In the ongoing second COVID-19 wave, a large number of patients are facing severe oxygen dependency and need hospitalisation. The drug is expected to save precious lives due to the mechanism of its operation in the infected cells. This also reduces the hospital stay of COVID-19 patients," the ministry had said.

The anti-COVID therapeutic application of the drug has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a leading laboratory of the DRDO, in collaboration with Dr Reddy's Laboratories (DRL) in Hyderabad.

The drug comes in powder form in a sachet and is taken orally by dissolving it in water, the ministry said.

In efficacy trends, patients treated with 2-DG showed a faster symptomatic cure than the standard of care (SoC) on various endpoints.

(With inputs from agencies)